Kilic, Zuhal published the artcileEvaluation of new indole and bromoindole derivatives as pp60c-Src tyrosine kinase inhibitors, Application of SU6656, the publication is Chemical Biology & Drug Design (2009), 74(4), 397-404, database is CAplus and MEDLINE.
A series of N-benzyl-indole-3-imine-, amine derivatives and their 5-bromo congeners were synthesized and their biol. activity were evaluated against the pp60c-Src tyrosine kinase target. To afford the imine derivatives, aldehydes were reacted with substituted benzylamines and the corresponding amine derivatives were obtained by NaBH4 reduction of these imines. Except insoluble N-benzyl-indole-3-imine derivatives, all the derivatives showed some activity against the kinase target. Screening of these compounds for their biol. activity revealed that among N-benzylindole derivatives, those bearing 5-bromo substitution have the enhanced potency, where the amine derivatives were more active than imines.
Chemical Biology & Drug Design published new progress about 330161-87-0. 330161-87-0 belongs to indole-building-block, auxiliary class Protein Tyrosine Kinase/RTK,Src, name is SU6656, and the molecular formula is C19H21N3O3S, Application of SU6656.
Referemce:
https://www.nature.com/articles/s41429-020-0333-2,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles