Koenig, Stefan G. published the artcileCopper-Catalyzed Synthesis of Indoles and Related Heterocycles in Renewable Solvents, Recommanded Product: Ethyl 6-cyano-1H-indole-2-carboxylate, the main research area is copper catalyst cross coupling acetamidoacetate bromobenzaldehyde renewable solvent; indolecarboxylate preparation green chem; fused heterocycle preparation green chem.
An efficient one-pot cascade to indoles and related fused heterocycles has been demonstrated in renewable solvents (EtOAc, 2-methyltetrahydrofuran), thereby eliminating the previously required dipolar aprotic solvent. The copper-catalyzed reaction proceeds with a range of bromobenzaldehydes to give products in good yields. E.g., in presence of CuI and Cs2CO3 under nitrogen in EtOAc, cross-coupling of 2-BrC6H4CHO and Et acetamidoacetate gave 59% indole derivative (I). In addition, the external ligand-free cross-coupling methodol. provides convenient access to an investigational treatment for central nervous system disorders.
ACS Sustainable Chemistry & Engineering published new progress about Cross-coupling reaction. 104291-81-8 belongs to class indole-building-block, name is Ethyl 6-cyano-1H-indole-2-carboxylate, and the molecular formula is C12H10N2O2, Recommanded Product: Ethyl 6-cyano-1H-indole-2-carboxylate.
Referemce:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles