Koenig, Stefan G. published the artcileA ligand-free, copper-catalyzed cascade sequence to indole-2-carboxylic esters, Formula: C12H10N2O2, the main research area is indole carboxylic ester preparation ligand free substituent effect; haloaryl aldehyde glycine amido ester heterocyclization copper catalyst.
A variety of indole-2-carboxylic esters, e.g. I, are accessible in yields up to 61% through a ligand-free, copper-catalyzed reaction of a series of com. available 2-halo aryl aldehydes with benign glycine amidoesters, including the common reagent Et acetamidoacetate. This one-pot, three-reaction format allows ready entry to the desired heterocycles from starting substrates in the reactivity order of iodo > bromo ≥ chloro substituents. An assortment of functional groups is tolerated, adding to the generality of this methodol.
Tetrahedron Letters published new progress about Amino esters Role: RCT (Reactant), RACT (Reactant or Reagent) (amido-). 104291-81-8 belongs to class indole-building-block, name is Ethyl 6-cyano-1H-indole-2-carboxylate, and the molecular formula is C12H10N2O2, Formula: C12H10N2O2.
Referemce:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles