Kopchuk, Dmitry S. et al. published their research in Organic & Biomolecular Chemistry in 2018 | CAS: 774-47-0

5,6-Difluoroindoline-2,3-dione (cas: 774-47-0) belongs to indole derivatives. The indole subunit is an almost ubiquitous component of biologically active natural products, and its study has been the focus of research for decades. They are capable of binding to a variety of receptors with high affinity and thus have applications in a wide range of therapeutic areas.COA of Formula: C8H3F2NO2

Studies on the interactions of 5-R-3-(2-pyridyl)-1,2,4-triazines with arynes: inverse demand aza-Diels-Alder reaction versus aryne-mediated domino process was written by Kopchuk, Dmitry S.;Nikonov, Igor L.;Khasanov, Albert F.;Giri, Kousik;Santra, Sougata;Kovalev, Igor S.;Nosova, Emiliya V.;Gundala, Sravya;Venkatapuram, Padmavathi;Zyryanov, Grigory V.;Majee, Adinath;Chupakhin, Oleg N.. And the article was included in Organic & Biomolecular Chemistry in 2018.COA of Formula: C8H3F2NO2 This article mentions the following:

The interactions between substituted 5-substituted-3-(2-pyridyl)-1,2,4-triazines I [R1 = H, Ph, indol-3-yl, etc. ; R2 = Ph, 4-BrC6H4, 4-O2NC6H4, etc.] with in-situ generated substituted aryne intermediates were studied. The reaction afforded either inverse demand (ID) aza-Diels-Alder products or 1,2,4-triazine ring rearrangement (domino) products as major ones depending on the nature of both the substituents at the C5 position of the 1,2,4-triazine core or in the aryne moiety. The structures of the key products were confirmed based on X-ray data. Based on the d. functional theor. (DFT) studies of the Diels-Alder transition state geometries, the influence of the nature of arynes on the direction of the 1,2,4-triazine transformation were proposed. In the experiment, the researchers used many compounds, for example, 5,6-Difluoroindoline-2,3-dione (cas: 774-47-0COA of Formula: C8H3F2NO2).

5,6-Difluoroindoline-2,3-dione (cas: 774-47-0) belongs to indole derivatives. The indole subunit is an almost ubiquitous component of biologically active natural products, and its study has been the focus of research for decades. They are capable of binding to a variety of receptors with high affinity and thus have applications in a wide range of therapeutic areas.COA of Formula: C8H3F2NO2

Referemce:
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Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles