Previous studies have identified that indole-oxidases are present in P. putida, whose major ligands are heterocyclic substrates and have an interesting affinity when the substrate is indole. 35737-15-6, formula is C26H22N2O4, Name is Fmoc-Trp-OH. These enzymes oxidize the ring so the substrate turns into Indigo. Synthetic Route of 35737-15-6.
Koshti, Bharti;Kshtriya, Vivekshinh;Naskar, Soumick;Narode, Hanuman;Gour, Nidhi research published 《 Controlled aggregation properties of single amino acids modified with protecting groups》, the research content is summarized as follows. The self-assembly of modified single amino acids has gained substantial attention due to their ease of synthesis, biocompatibility and ability to assemble into distinct structures which can potentially be used for a wide range of applications. Herein, we report the self-assembly of modified single amino acids, i.e. charged aliphatic and aromatic amino acids, which are functionalized with different protecting groups such as 9-fluorenylmethoxycarbonyl (Fmoc), tert-butyloxycarbonyl (Boc), N-carboxybenzyl (Cbz) and tert-Bu (tBu) into distinct structures. The self-assembled structures formed by these modified charged aliphatic and aromatic single amino acids were very interesting and distinct, and also showed the propensity of controlled morphol. transitions at varying concentrations and temperatures The modified single amino acids self-assembled into different well-defined morphologies such as spheres, flowers, fibers, rods and unusual broom-like structures as characterized by various microscopic techniques. The solution state 1H-NMR, ATR-FTIR studies and control experiments with tannic acid further provided useful insights into the role of intermol. interactions which governs the process of self-assembly and implicates the crucial role of pi-pi stacking and hydrogen bonding in structure formation.
Synthetic Route of 35737-15-6, Nalpha-FMOC-L-Tryptophan,also known as Fmoc-Trp-OH， is a useful research compound. Its molecular formula is C26H22N2O4 and its molecular weight is 426.5 g/mol. The purity is usually 95%.
Nα-Fmoc-L-Tryptophan is an N-Fmoc protected form of L-Tryptophan (T947210). L-Tryptophan is an essential amino acid that is important for cell proliferation and the biosynthesis of proteins. It is a precursor to Serotonin (HCl: S274980), a neurotransmitter that compound that aids in sleep and mental state. L-Tryptophan is also thought to cause eosinophilia-myalgia syndrome.
Fmoc-Trp-OH is an amino acid derivative
Fmoc-L-Trp-OH is an amide that contains a low bioavailability and inhibits the transfer of amino acids to ribosomes. It has been shown to inhibit the growth of cancer cells in cell culture and to have antimicrobial activity. Fmoc-L-Trp-OH is synthesized by reacting Naphthalene with glycine, followed by hydrolysis of the ester group under trifluoroacetic acid. The product is then conjugated with a polypeptide. This method of synthesis was developed as a way to produce peptides that are difficult to synthesize using solid-phase chemistry., 35737-15-6.
Referemce:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles