Condensation of o-(bromomethyl)benzoic acid with amines was written by Kovtunenko, V. A.;Tyltin, A. K.;Dobrenko, T. T.;Babichev, F. S.. And the article was included in Ukrainskii Khimicheskii Zhurnal (Russian Edition) in 1983.Quality Control of 2-Phenylisoindolin-1-one This article mentions the following:
Isoindolinones I [R = Me, (un)substituted Ph, PhCH2, H, 1-C10H7] were prepared in 43-80% yields by cyclocondensation of o-(XCH2)C6H4CO2R1 (R1 = H, Me, X = Br, Cl) with RNH2. Heating I (R = Me, Ph, 4-MeOC6H4, 4-MeC6H4) in the presence of P4S10 gave 48-55% II. In the experiment, the researchers used many compounds, for example, 2-Phenylisoindolin-1-one (cas: 5388-42-1Quality Control of 2-Phenylisoindolin-1-one).
2-Phenylisoindolin-1-one (cas: 5388-42-1) belongs to indole derivatives. Indole, first isolated in 1866, and it is commonly synthesized from phenylhydrazine and pyruvic acid, although several other procedures have been discovered. More than 200 indole derivatives have already been marketed as drugs or are under advanced stages of clinical trials.Quality Control of 2-Phenylisoindolin-1-one
Referemce:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles