Kraynack, Erica A. published the artcileAn improved procedure for the regiospecific synthesis of electron deficient 4- and 6-substituted isatins, Related Products of indole-building-block, the main research area is isatin electron deficient regiospecific preparation; nitrochlorobenzene substitution malonate; chloroisatin regiospecific preparation; benzoylisatin regiospecific preparation.
The regiospecific synthesis of C-4 and C-6 substituted isatins I (R = H, Cl; R1 = H, Cl; R2 = H, Cl, Bz, 4-MeC6H4CO, 4-ClC6H4CO, 4-MeOC6H4CO) in four steps from halonitrobenzenes II (X = Cl, F) was investigated for a variety of substrates. The procedure makes use of readily available, easily handled materials and in most cases purification of neither intermediates nor final products is required. Yields of isatins I are between 26 and 75%. Improved yields of known isatins are reported as well as the syntheses of previously unreported isatins. This method, taken together with known procedures, provides for the synthesis of the full complement of isatin regioisomers.
Tetrahedron Letters published new progress about Regiochemistry. 71293-59-9 belongs to class indole-building-block, name is 5,6-Dichloroindolin-2-one, and the molecular formula is C8H5Cl2NO, Related Products of indole-building-block.
Referemce:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles