Kroeger, A. Pia P.; Paats, Jan-Willem D.; Boonen, Roy J. E. A.; Hamelmann, Naomi M.; Paulusse, Jos M. J. published the artcile< Pentafluorophenyl-based single-chain polymer nanoparticles as a versatile platform towards protein mimicry>, COA of Formula: C30H36N4O2, the main research area is pentafluorophenyl single chain polymer nanoparticle protein mimicry versatile platform.
Proteins are biopolymers folded into 3D-structures and are omnipresent in biol. systems, where they fulfil a wide array of complex functions. Mimicking the exceptional characteristics of proteins with synthetic analogs may likewise give unprecedented control over a nanomaterial’s pharmacokinetic behavior, enabling controlled delivery of therapeutics or imaging agents. Recent advances in polymer science have enabled the formation of bio-inspired single-chain polymer nanoparticles (SCNPs), which are formed by intramol. collapse of individual polymer chains, and display sizes ranging from 5-20 nm. Here, we describe the preparation of SCNPs containing activated ester moieties, facilitating SCNP functionalization without altering its backbone structure. Pentafluorophenyl-functional SCNPs were prepared through intramol. thiol-Michael addition crosslinking of thiol-functional precursor copolymers. Post-formation functionalization of the resulting SCNPs through substitution of the activated pentafluorophenyl esters with a variety of amines resulted in a series of water-soluble SCNPs with fluorescent labels, ‘click’ functionality, amino acids and even peptides. This synthetic strategy offers a straightforward method towards SCNP modification and SCNP-protein hybrids, giving access to easily adjustable physicochem. properties and protein mimicry.
Polymer Chemistry published new progress about Cytotoxicity. 950846-89-6 belongs to class indole-building-block, and the molecular formula is C30H36N4O2, COA of Formula: C30H36N4O2.
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Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles