Synthesis and anticancer activity evaluation of 3-(4-oxo-2-thioxothiazolidin-5-yl)-1H-indole-carboxylic acids derivatives was written by Kryshchyshyn-Dylevych, Anna;Garazd, Myroslav;Karkhut, Andrew;Polovkovych, Sviatoslav;Lesyk, Roman. And the article was included in Synthetic Communications in 2020.Recommanded Product: 167631-84-7 This article mentions the following:
A mild and efficient method for the synthesis of 1-oxo-9H-thiopyrano[3,4-b]indole-3-carboxylic acids I (R = F, H, OMe) and dimerized 3-(4-carboxy-1H-3-indolyl)-2-propenoic acids II (R1 = Me, Et) via alk. hydrolysis of 3-(rhodanin-5-yl)-1H-indole-2-carboxylic acids derivatives III (R2 = H, methoxycarbonyl; R3 = H, methoxycarbonyl, carboxy; R4 = H, Me, Et) was elaborated. Anticancer activity screening in NCI60-cell lines assay allowed identification of III (R = F; R2 = R4 = H; R3 = methoxycarbonyl) with significant antimitotic activity at micromolar and submicromolar concentrations In the experiment, the researchers used many compounds, for example, Methyl 5-fluoro-1H-indole-2-carboxylate (cas: 167631-84-7Recommanded Product: 167631-84-7).
Methyl 5-fluoro-1H-indole-2-carboxylate (cas: 167631-84-7) belongs to indole derivatives. Indole is an important structural motif of various drugs, therapeutic leads besides its prevalence in numerous natural products, agrochemicals, perfumery, and dyes. Due to this activity, the indole ring system has become an important component or intermediate in the synthesis of heterocycles.Recommanded Product: 167631-84-7
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Indole alkaloid derivatives as building blocks of natural products from闂佽壈浜崹淇沜illus thuringiensis闂佽壈浜粋鍧闂佽壈浜崹淇沜illus velezensis闂佽壈浜粋鍧 their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles