Indole, also called Benzopyrrole, a heterocyclic organic compound occurring in some flower oils, such as jasmine and orange blossom, in coal tar, and in fecal matter. 19005-93-7, formula is C9H7NO, Name is 1H-Indole-2-carbaldehyde. It is used in perfumery and in making tryptophan, an essential amino acid, and indoleacetic acid (heteroauxin), a hormone that promotes the development of roots in plant cuttings. Safety of 1H-Indole-2-carbaldehyde.
Kumar, Gautam;Goutami Godavari, Ambati;Tambat, Rushikesh;Kumar, Siva;Nandanwar, Hemraj;Elizabeth Sobhia, M.;Jachak, Sanjay M. research published 《 Synthesis, biological evaluation and computational studies of acrylohydrazide derivatives as potential Staphylococcus aureus NorA efflux pump inhibitors》, the research content is summarized as follows. The NorA efflux pump decreases the intracellular concentration of fluoroquinolones (ciprofloxacin, norfloxacin) by effluxing them from Staphylococcus aureus cells. The synthesis of novel acrylohydrazides I [R1 = 2-furyl, 5-nitro-2-furyl, 4-(PhCH2O)C6H4, 3,4,5-(MeO)3C6H2; R2 = 4-FC6H4, 4-pyridyl, 2-imidazolyl, 5-bromo-2-thienyl, 2-pyrrolyl, etc.] was achieved using well-known reactions, and the products were characterized by various spectroscopy techniques. The synthesized 50 compounds I were evaluated for the NorA efflux pump inhibition activity against S. aureus SA-1199B (norA++) and K1758 (norA-) strains. The study provided two most active compounds viz. I (R1 = 2-furyl; R2 = 5-bromo-2-furyl) and I [R1 = 3,4,5-(MeO)3C6H2; R2 = 2-pyrrolyl]. The compound I (R1 = 2-furyl; R2 = 5-bromo-2-furyl) was found to be the most active in potentiating effect of norfloxacin and it also showed enhanced uptake, efflux inhibition in ethidium bromide assay. Furthermore, this compound also enhanced post antibiotic effect and reduced mutation prevention concentration of norfloxacin. The homol. modeling study was performed to elucidate three-dimensional structure of NorA. Docking studies of potent mols. were done to find the binding affinity and interaction with active site residues. Furthermore, all the tested compounds exhibited good ADME and drug-likeness properties in-silico.
Safety of 1H-Indole-2-carbaldehyde, 1H-Indole-2-carbaldehyde is a useful research compound. Its molecular formula is C9H7NO and its molecular weight is 145.16 g/mol. The purity is usually 95%.
1H-Indole-2-carbaldehyde is a useful research chemical used as a reactant in the synthesis of substituted 2-amino-4H-chromenes and benzochromenes using K2CO3 as catalyst.
1H-Indole-2-carbaldehyde is a solvent that has been used in the protein data and molecular modeling study. The 1H NMR spectrum of this compound showed an intense signal at δ 4.8 ppm, corresponding to the hydroxyl proton. This solvent also has fluorescence properties, as shown by its photophysical and structural analysis. The 1H-indole-2-carbaldehyde molecule has an active methylene group and an oxindole ring with amine substituents., 19005-93-7.
Referemce:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles