Kumar, Nadavala Siva et al. published their research in Pharmaceutical Chemistry Journal in 2018 |CAS: 79815-20-6

The Article related to perindopril impurity analysis lc ms stability, Pharmaceutical Analysis: Synthetic Organic Compounds and other aspects.Application of 79815-20-6

On July 31, 2018, Kumar, Nadavala Siva; Sreenivasulu, Vudagandla; Ramachandra, Bondigalla; Asif, Mohammad; Ibrahim, Ahmed A. published an article.Application of 79815-20-6 The title of the article was A stability-indicating LC-MS method for determination of perindopril and its process related impurities. And the article contained the following:

Perindopril erbumine belongs to the member of angiotensin-converting enzyme inhibitors group used in the treatment of heart failure and hypertension. Asimple and highly sensitive LC-MS method has been developed for the simultaneous determination of three process-related impurities (L-norvaline, L-norvaline Et ester HCl, and (S)-indoline-2-carboxylic acid) in perindopril. Samples were separated using 5 mM ammonium formate (A) and acetonitrile/methanol (B) as the mobile phase on a Symmetry C18 column (75 mm × 4.6 mm, 3.5 μm) using gradient elution mode at a flow rate of 0.6 mL/min. The proposed method was validated as per ICH guidelines and can be used for quality testing of perindopril and determining its process-related impurities in pharmaceuticals. The experimental process involved the reaction of H-Idc-OH(cas: 79815-20-6).Application of 79815-20-6

The Article related to perindopril impurity analysis lc ms stability, Pharmaceutical Analysis: Synthetic Organic Compounds and other aspects.Application of 79815-20-6

Referemce:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles