On August 9, 2000, Kuwano, Ryoichi; Sato, Koji; Kurokawa, Takashi; Karube, Daisuke; Ito, Yoshihiko published an article.Name: H-Idc-OH The title of the article was Catalytic asymmetric hydrogenation of heteroaromatic compounds, indoles. And the article contained the following:
Indoles I (R = Bu, Me2CHCH2, Ph, MeO2C; R1 = MeCO, Me3COCO; R2 = H, Me, F3C; R3 = H, MeO, F3C) are reduced enantioselectively to nonracemic indolines II in 83-100% yields and 78-95% ee by a rhodium norbornadiene catalyst in the presence of a bis(diphenylphosphinoethyl)biferrocene ligand. E.g., indolecarboxylate I (R = MeO2C; R1 = MeCO; R2 = R3 = H) was stirred in isopropanol in the presence of cesium carbonate, [Rh(norbornadiene)2]+SbF6- and the bis(diphenylphosphinoethyl)biferrocene (S,S)-(R,R)-PhTRAP under hydrogen at 5.0 MPa and at 60° to give II (R = MeO2C; R1 = MeCO; R2 = R3 = H) in 95% yield and 95% ee. The [Rh(norbornadiene)2]+SbF6–(S,S)-(R,R)-PhTRAP catalytic system is the first hydrogenation catalyst found to reduce five-membered heterocyclic systems enantioselectively. The experimental process involved the reaction of H-Idc-OH(cas: 79815-20-6).Name: H-Idc-OH
The Article related to indoline enantioselective preparation, indole enantioselective hydrogenation rhodium norbornadiene complex phtrap ligand, catalytic asym hydrogenation heteroaromatic compound and other aspects.Name: H-Idc-OH
Referemce:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles