On December 7, 2012, Lagrange, Alain; Mignon, Marie published a patent.Electric Literature of 52537-00-5 The title of the patent was Hair dye composition comprising an indoline coupler in a medium rich in fatty substances. And the patent contained the following:
The present invention relates to a composition for dyeing keratin fibers, such as hair, comprising: a fatty substance, a surfactant; an oxidation base, one or more indoline couplers (I, R1 = e.g., H, C1-10 alkyl or alkenyl; R2 = halo, C1-10 alkyl or alkenyl, and 2 radicals R2 borne by adjacent carbon atoms forming a 5-8 membered ring; and n = 0-4; R3,R4 = H, halo halo, C1-10 alkyl or alkenyl, or C1-8 alkoxy); and the fatty substance content at 25% by weight The present invention also relates to a process of using this composition in the presence of a chem. oxidizing agent, and to multicompartment devices suitable for the implementation of the invention. Thus, a formulation containing 4-(3-aminopyrazolo[1,5-a]pyridin-2-yl)-1,1-dimethylpiperazin-1-ium chloride hydrochloride provides a raise in 螖Elab color much more important on 90% white hair and therefore a much better staining in the root than that obtained using a comparative composition The experimental process involved the reaction of 6-Chloro-2,3-dihydro-1H-indole(cas: 52537-00-5).Electric Literature of 52537-00-5
The Article related to hair dye indoline coupler fatty substance, Essential Oils and Cosmetics: Hair Preparations and other aspects.Electric Literature of 52537-00-5
Referemce:
Indole alkaloid derivatives as building blocks of natural products from聽Bacillus thuringiensis聽and聽Bacillus velezensis聽and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles