Chemo-selective control of Ritter-type reaction by coordinatively unsaturated inorganic salt hydrates was written by Lai, Huifang;Xu, Jiexin;Lin, Jin;Su, Biling;Zha, Daijun. And the article was included in Organic Chemistry Frontiers in 2022.Application In Synthesis of 2-Phenylisoindolin-1-one This article mentions the following:
The Ritter-type reaction, without relying on a pre-installed functional group, is a highly efficient tool for the construction of amides. However, the intrinsic chemo-selectivity that determines the generation of amides or byproducts limits the efficiency and yield of the reaction. From 68 different types of hydrates studied, a coordinatively unsaturated inorganic salt hydrate, MgSO4路2H2O, controlled chemo-selectivity and eliminated the shortcomings of other synthesis approaches. To rationalize the differences in selectivity of inorganic salt hydrates, their corresponding water content, alkalinity, anions and cations were analyzed. MgSO4路2H2O was used with diverse scaffolds and C-H oxygenations, which demonstrated its generality in synthetic utility. Because it is readily available and it significantly improves yield, MgSO4路2H2O will have broad application for Ritter-type reactions. In the experiment, the researchers used many compounds, for example, 2-Phenylisoindolin-1-one (cas: 5388-42-1Application In Synthesis of 2-Phenylisoindolin-1-one).
2-Phenylisoindolin-1-one (cas: 5388-42-1) belongs to indole derivatives. Indole could be stereoselectively alkylated with chiral cyclopentyl sulfone reagent. In addition to indole, the strain-release chemistry worked for numerous substrates including amines, alcohols, thiols, carboxylic acids, imidazoles, and pyrazoles.Application In Synthesis of 2-Phenylisoindolin-1-one
Referemce:
Indole alkaloid derivatives as building blocks of natural products from聽Bacillus thuringiensis聽and聽Bacillus velezensis聽and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles