Asymmetric Synthesis of 3-Allyloxindoles and 3-Allenyloxindoles by Scandium(III)-Catalyzed Claisen Rearrangement Reactions was written by Lai, Zeng-Wei;Liu, Chuan;Sun, Hongbin;You, Shu-Li. And the article was included in Chinese Journal of Chemistry in 2017.Application of 773134-49-9 This article mentions the following:
Scandium-catalyzed asym. Claisen rearrangement reactions of 2-allyloxyindoles and 2-propargyloxyindoles provide a novel approach to diverse 3-allyloxindoles and 3-allenyloxindoles in excellent yields (up to 99%) and enantioselectivity (up to 99% ee) under mild reaction conditions. The scandium catalyst was derived from Sc(OTf)3 and Pybox ligand. In the experiment, the researchers used many compounds, for example, Methyl 7-methyl-1H-indole-3-carboxylate (cas: 773134-49-9Application of 773134-49-9).
Methyl 7-methyl-1H-indole-3-carboxylate (cas: 773134-49-9) belongs to indole derivatives. Indole, first isolated in 1866, and it is commonly synthesized from phenylhydrazine and pyruvic acid, although several other procedures have been discovered. In addition to indole, the strain-release chemistry worked for numerous substrates including amines, alcohols, thiols, carboxylic acids, imidazoles, and pyrazoles.Application of 773134-49-9
Referemce:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles