An efficient synthesis of versatile synthon 3-chlorooxindoles with NaCl/oxone was written by Lakshmi Reddy, Vanammoole;Prathima, Parvathaneni Sai;Rao, Vaidya Jayathirtha;Bikshapathi, Raktani. And the article was included in New Journal of Chemistry in 2018.Category: indole-building-block This article mentions the following:
The present work describes an expedient approach for the direct conversion of indole-3-carboxaldehyde to 3-chlorooxindoles, e.g., I using a simple sustainable synthetic method. From an environmental perspective, a combination of NaCl/oxone in a CH3CN:H2O (1:1) system was developed for direct oxidative chlorination of a wide array of indole derivatives This chlorination strategy is more viable, remarkably cheaper and provides easy access to potential 3-chlorooxindoles. In addition, this environmentally benign method can also be applicable for constructing isatin derivatives in good yields. In the experiment, the researchers used many compounds, for example, 5-Chloroindole-3-carboxaldehyde (cas: 827-01-0Category: indole-building-block).
5-Chloroindole-3-carboxaldehyde (cas: 827-01-0) belongs to indole derivatives. Indole, first isolated in 1866, and it is commonly synthesized from phenylhydrazine and pyruvic acid, although several other procedures have been discovered. Indole plays a fundamental role for QS in E. coli, being one of the signal molecules responsible for the transcription of a variety of genes (gabT, and tnaB ASTD). Category: indole-building-block
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Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles