Lamotte, Yann published the artcileSynthesis and biological activities of novel indole derivatives as potent and selective PPARγ modulators, Synthetic Route of 57663-18-0, the main research area is biphenylcarboxylic acid indolylmethyl preparation peroxisome proliferator activated receptor modulator; acid biphenylcarboxylic indolylmethyl preparation PPAR gamma modulator potency SAR; indolylmethyl biphenylcarboxylic acid preparation antidiabetic PPAR partial agonist activity.
Starting from the structure of Telmisartan, a new series of potent and selective PPARγ modulators was identified. The synthesis, in vitro and in vivo evaluation of the most potent compounds were reported and the X-ray structure of compound I bound to the PPARγ ligand binding domain was described.
Bioorganic & Medicinal Chemistry Letters published new progress about Hematocrit. 57663-18-0 belongs to class indole-building-block, name is Methyl 2-methyl-1H-indole-5-carboxylate, and the molecular formula is C11H11NO2, Synthetic Route of 57663-18-0.
Referemce:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles