A concise and rapid approach to the marine natural product streptochlorin and its analogs was written by Lee, Jong Seok;Shin, Junho;Lee, Hyi-Seung;Shin, Hee Jae;Lee, Yeon-Ju. And the article was included in Bulletin of the Korean Chemical Society in 2013.Quality Control of N-(2-(1H-Indol-3-yl)ethyl)acetamide This article mentions the following:
The synthesis of the target compounds was achieved by a strategy involving a a van Leusen oxazole synthesis and a Gabriel-Robinson reaction (cyclodehydration). The title compounds thus formed included a streptochlorin analog (I) and related substances [3-(4-chloro-5-oxazolyl)-1H-indole, streptochlorin derivatives and analogs]. The synthesis of the target compounds was achieved using 3-formyl-1H-indole-1-carboxylic acid 1,1-dimethylethyl ester derivatives and 1-[(isocyanomethyl)sulfonyl]-4-methylbenzene (TosMIC) as starting materials. In the experiment, the researchers used many compounds, for example, N-(2-(1H-Indol-3-yl)ethyl)acetamide (cas: 1016-47-3Quality Control of N-(2-(1H-Indol-3-yl)ethyl)acetamide).
N-(2-(1H-Indol-3-yl)ethyl)acetamide (cas: 1016-47-3) belongs to indole derivatives. In addition to tryptophan, indigo, and indoleacetic acid, numerous compounds obtainable from plant or animal sources contain the indole molecular structure.Indole was synthesized in moderate yield via an o-naphthoquinone catalyzed tandem cross-coupling of substituted aniline and benzylamine under aerobic oxidation conditions.Quality Control of N-(2-(1H-Indol-3-yl)ethyl)acetamide
Referemce:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles