Characterization of a reference standard for qualification of differential scanning calorimetry intended for purity determination in certification of pharmaceutical reference standards was written by Leontiev, D. A.;Volovyk, N. V.;Bevz, O. V.;Vashchenko, O. V.;Gryzodub, O. I.. And the article was included in Journal of Pharmaceutical Sciences and Research in 2018.Recommanded Product: 1-(2,6-Dichlorophenyl)-2-indolinone This article mentions the following:
To select and characterize a reference standard for equipment qualification suitable for performance verification in the certification of pharmaceutical reference standards by differential scanning calorimetry (DSC) based on the metrol. criteria of the State Pharmacopoeia of Ukraine. The purity analyses were performed in accordance with a standard procedure by DSC. For the selected candidate, the results of purity determination were compared with those obtained by gas chromatog. The metrol. criteria for results of purity determination in the certification of pharmaceutical reference standards by DSC used as an alternative method were formulated. A candidate material of cholesterol for performance verification of DSC met the established requirements. For cholesterol, the characteristics of purity, m.p. and enthalpy of fusion were certified simultaneously. The further study of intra- and inter-laboratory variation of the results is required to characterize the uncertainty of the purity determination A candidate material of cholesterol can be used as a reference standard for equipment qualification for purity determination by DSC for characterization of pharmaceutical reference standards In the experiment, the researchers used many compounds, for example, 1-(2,6-Dichlorophenyl)-2-indolinone (cas: 15362-40-0Recommanded Product: 1-(2,6-Dichlorophenyl)-2-indolinone).
1-(2,6-Dichlorophenyl)-2-indolinone (cas: 15362-40-0) belongs to indole derivatives. Indole, also called Benzopyrrole, a heterocyclic organic compound occurring in some flower oils, such as jasmine and orange blossom, in coal tar, and in fecal matter. They are capable of binding to a variety of receptors with high affinity and thus have applications in a wide range of therapeutic areas.Recommanded Product: 1-(2,6-Dichlorophenyl)-2-indolinone
Referemce:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles