Recently I am researching about EZH2 INHIBITOR 3-DEAZANEPLANOCIN; IN-VITRO EVALUATION; ANTIPROLIFERATIVE ACTIVITY; TUBULIN POLYMERIZATION; DERIVATIVES BEARING; CYTOTOXIC ACTIVITY; CANCER; CARDIOTOXICITY; ANTIOXIDANTS; THERAPY, Saw an article supported by the Hamdard National Foundation (HNF), New Delhi. Published in WILEY-V C H VERLAG GMBH in WEINHEIM ,Authors: Iqbal, MA; Husain, A; Alam, O; Khan, SA; Ahmad, A; Haider, MR; Alam, MA. The CAS is 100-83-4. Through research, I have a further understanding and discovery of 3-Hydroxybenzaldehyde. Category: indole-building-block
In this study, two series of imidazopyridine-linked thiazolidinone rings (5a-hand6a-h) constituting 16 new compounds were synthesized and tested for their antiproliferative activity against a panel of three human cancer cell lines, that is, MCF-7 (human breast cancer), A549 (human lung cancer), and DU145 (human prostate cancer). Three compounds,5h,6f, and6h, exhibited remarkable results against all three cell lines, but compound6hwas found to be the most active one against the breast cancer cell line. Among all the synthesized compounds,6hdisplayed the highest antioxidant results. Furthermore, the potent compounds5h,6f, and6hshowed no signs of toxicity at doses ranging from 50 to 500 mg/kg of animal body weight. The biochemical parameters (SGOT and SGPT) of compound6hnearly matched the control in hepatotoxicity studies. The molecular docking and MM-GBSADG binding studies are in agreement with the in vitro anticancer and antioxidant activity results. The most promising compound6hwas found to have the highest docking score and binding energy, and its absorption, distribution, metabolism, and excretion (ADME) parameters are in the acceptable range. Thus, it can be concluded that6h, an imidazopyridine derivative endowed with a thiazolidinone ring system, has the potential to be developed as an anticancer agent.
Category: indole-building-block. About 3-Hydroxybenzaldehyde, If you have any questions, you can contact Iqbal, MA; Husain, A; Alam, O; Khan, SA; Ahmad, A; Haider, MR; Alam, MA or concate me.
Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles