Recently I am researching about III POLYKETIDE SYNTHASE; NF-KAPPA-B; METABOLITES; MECHANISM; OXIDASE, Saw an article supported by the Specific Research Project of Guangxi for Research Bases and Talents, P. R. China [AD18281066]; Science and Technology Major Project of Guangxi, P. R. China [AA18242026]. Name: 3-(Trifluoromethyl)phenol. Published in ACADEMIC PRESS INC ELSEVIER SCIENCE in SAN DIEGO ,Authors: Wu, WX; Mu, Y; Liu, B; Wang, ZX; Guan, PP; Han, L; Jiang, MG; Huang, XS. The CAS is 98-17-9. Through research, I have a further understanding and discovery of 3-(Trifluoromethyl)phenol
Violacin A, a chromanone derivative, isolated from a fermentation broth of Streptomyces violaceoruber, has excellent anti-inflammatory potential. Herein, a biogenetically modeled approach to synthesize violacin A and twenty-five analogues was described, which involved the preparation of aromatic polyketide precursor through Claisen condensation and its spontaneous cyclization. The inhibitory effect on nitric oxide (NO) production of all synthetic molecules was evaluated by lipopolysaccharide (LPS)-induced Raw264.7 cells. The results revealed that introduction of aliphatic amine moieties on C-7 obviously improved the anti-inflammation effect of violacin A, and also the aromatic ether instead of ketone group at side chain was favorable to increase the activity. Among them, analogue 7a and 16d were screened as the most effective anti-inflammatory candidates. Molecular mechanism research revealed that 7a and 16d acquired anti-inflammatory ability due to the inhibition of NF-KB signaling pathway.
Name: 3-(Trifluoromethyl)phenol. About 3-(Trifluoromethyl)phenol, If you have any questions, you can contact Wu, WX; Mu, Y; Liu, B; Wang, ZX; Guan, PP; Han, L; Jiang, MG; Huang, XS or concate me.
Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles