Teixeira, RR; da Silva, AM; Siqueira, RP; Goncalves, VHS; Pereira, HS; Ferreira, RS; Costa, AV; de Melo, EB; Paula, FR; Ferreira, MMC; Bressan, GC in [Teixeira, Robson R.] Univ Fed Vicosa, Dept Quim, Av PH Rolfs S-N, BR-36570900 Vicosa, MG, Brazil; [da Silva, Adalberto M.] Inst Fed Educ Ciencia & Tecnol Catarinense, Campus Araquari,Rodovia BR 280,Km 27,CP 21, BR-89245000 Araquari, SC, Brazil; [Siqueira, Raoni P.; Goncalves, Victor Hugo S.; Pereira, Higor S.; Bressan, Gustavo C.] Univ Fed Vicosa, Dept Bioquim & Biol Mol, Av PH Rolfs S-N, BR-36570900 Vicosa, MG, Brazil; [Ferreira, Rafaela S.] Univ Fed Minas Gerais, Dept Bioquim & Imunol, Av Antonio Carlos 6627, BR-31270901 Belo Horizonte, MG, Brazil; [Costa, Adilson, V] Univ Fed Espirito Santo, Dept Quim & Fis, Alto Univ S-N, BR-29500000 Alegre, ES, Brazil; [de Melo, Eduardo B.] Univ Estadual Oeste Parana UNIOESTE, Dept Farm, LQMAT, Rua Univ 2069, BR-85819110 Cascavel, PR, Brazil; [Paula, Favero R.] Univ Fed Pampa UNIPAMPA, Dept Farm, BR 472,Km 592,POB 118, BR-97500970 Uruguaiana, RS, Brazil; [Ferreira, Marcia M. C.] Univ Estadual Campinas, Inst Quim, BR-13084971 Campinas, SP, Brazil published Synthesis of Nerol Derivatives Containing a 1,2,3-Triazole Moiety and Evaluation of Their Activities against Cancer Cell Lines in 2019.0, Cited 51.0. Recommanded Product: Benzyl Alcohol. The Name is Benzyl Alcohol. Through research, I have a further understanding and discovery of 100-51-6.
In the present investigation, a collection of twenty two nerol derivatives, containing 1,2,3-triazolic appendages, was synthesized and screened in vitro for their cytotoxic activity against HL60, Nalm6, and Jurkat human leukemia cells as well as against B16F10 (melanoma cell line). In most cases, derivatives were able to reduce cell viability. The most potent compound (Z)-4-(((3,7-dimethylocta-2,6-dien-1-yl)oxy)methyl)-1-(4-(trifluoromethoxy)benzyl)1H-1,2,3 triazole showed antiproliferative activity against Jurkat cells and reduced B16F10 cell migration. Physicochemical properties of the compounds were calculated in order to evaluate their potential for drug development. Most of the evaluated physicochemical parameters seemed to be favorable for drug development. In addition, for a better understanding of the biological activity results, 3D quantitative structure-activity relationship (QSAR) studies were carried out. 3D-QSAR studies indicate that the anticancer activities observed for the cell lines HL60 and Jurkat may occur by a similar mechanism of action and the same was found for the Nalm6 and B16F10 cell lines.
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Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles