Reusable Bronsted Acidic Ionic Liquid Efficiently Catalyzed N-Formylation and N-Acylation of Amines was written by Li, Chun;Wang, Mengna;Lu, Xunhua;Zhang, Ling;Jiang, Jian;Zhang, Lin. And the article was included in ACS Sustainable Chemistry & Engineering in 2020.Reference of 1016-47-3 This article mentions the following:
We disclose efficient and green N-formylation and N-acylation methodologies of various amines with carboxylic acids for the synthesis of versatile amides in the presence of Bronsted acidic ionic liquid Furthermore, the N-formylation and N-acylation with DMF and DMA have also been achieved in the same catalytic system. Notably, the catalyst in this catalytic solvent-free protocol could be easily recycled for up to five consecutive cycles with slight loss of activity. Novel, efficient, and green N-formylation and N-acylation catalyzed by reusable and metal-free Bronsted acidic ionic liquids without cocatalyst and solvent are presented. In the experiment, the researchers used many compounds, for example, N-(2-(1H-Indol-3-yl)ethyl)acetamide (cas: 1016-47-3Reference of 1016-47-3).
N-(2-(1H-Indol-3-yl)ethyl)acetamide (cas: 1016-47-3) belongs to indole derivatives. In addition to tryptophan, indigo, and indoleacetic acid, numerous compounds obtainable from plant or animal sources contain the indole molecular structure. Indole plays a fundamental role for QS in E. coli, being one of the signal molecules responsible for the transcription of a variety of genes (gabT, and tnaB ASTD). Reference of 1016-47-3
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