Li, Ming et al. published their research in ACS Medicinal Chemistry Letters in 2017 | CAS: 4769-96-4

6-Nitro-1H-indole (cas: 4769-96-4) belongs to indole derivatives. In addition to tryptophan, indigo, and indoleacetic acid, numerous compounds obtainable from plant or animal sources contain the indole molecular structure. In addition to indole, the strain-release chemistry worked for numerous substrates including amines, alcohols, thiols, carboxylic acids, imidazoles, and pyrazoles.Recommanded Product: 4769-96-4

Indolylalkyltriphenylphosphonium Analogues Are Membrane-Depolarizing Mycobactericidal Agents was written by Li, Ming;Nyantakyi, Samuel A.;Gopal, Pooja;Aziz, Dinah binte;Dick, Thomas;Go, Mei-Lin. And the article was included in ACS Medicinal Chemistry Letters in 2017.Recommanded Product: 4769-96-4 This article mentions the following:

Agents that selectively target the mycobacterial membrane could potentially shorten treatment time for tuberculosis, reduce relapse and curtail emergence of resistant strains. The lipophilicity and extensive charge delocalized state of the triphenylphosphonium (TPP) cation strongly favor accumulation within bacterial membranes. Here we explored the antimycobacterial activities and membrane targeting properties of indolylalkyltriphenylphosphonium analogs. The most active analogs preferentially inhibited growth of Mycobacterium tuberculosis H37Rv (MIC50 2-4 μM) and were cidal against Mycobacterium bovis BCG (MBC99 3 μM). In spite of their propensity to accumulate within membranes, we found no evidence that these compounds permeabilized mycobacterial membranes or induced cell-envelope stress. Our investigations indicated that the cidal effects of these compounds stem from sustained depolarization of mycobacterial membranes and ensuing disruptive effects on electron transfer and cell division. In the experiment, the researchers used many compounds, for example, 6-Nitro-1H-indole (cas: 4769-96-4Recommanded Product: 4769-96-4).

6-Nitro-1H-indole (cas: 4769-96-4) belongs to indole derivatives. In addition to tryptophan, indigo, and indoleacetic acid, numerous compounds obtainable from plant or animal sources contain the indole molecular structure. In addition to indole, the strain-release chemistry worked for numerous substrates including amines, alcohols, thiols, carboxylic acids, imidazoles, and pyrazoles.Recommanded Product: 4769-96-4

Referemce:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles