Ni-Catalyzed asymmetric hetero-Diels-Alder reactions of conjugated vinyl azides: Synthesis of chiral azido polycycles was written by Li, Shunian;Lu, Haifeng;Xu, Zhenghu;Wei, Fang. And the article was included in Organic Chemistry Frontiers in 2021.COA of Formula: C8H3F2NO2 This article mentions the following:
The authors describe an efficient Ni(II)/Feng ligand-catalyzed asym. hetero-Diels-Alder reaction between conjugated vinyl azides RC(:CH2)N3 [R = 1-cyclohexenyl, 1-cyclopentenyl, C6H5CH:CH, C6H5C(:CH2)] and carbonyl groups in compounds such as isatins I (R1 = H, 5,6-F2, 7-Br, 5-Me, etc.) and R2C(O)C(O)OR3 (R2 = H, Ph, 4-MeOC6H4, 4-FC6H4, 4-MeC6H4, R3 = Me, Et). This method provides a platform for the synthesis of complicated chiral azido polycycles II (R4 = H, 10,11-F2, 9-Br, 11-OCF3, 11-Me, etc.) and III in high yields and excellent enantioselectivities. In the experiment, the researchers used many compounds, for example, 5,6-Difluoroindoline-2,3-dione (cas: 774-47-0COA of Formula: C8H3F2NO2).
5,6-Difluoroindoline-2,3-dione (cas: 774-47-0) belongs to indole derivatives. In addition to tryptophan, indigo, and indoleacetic acid, numerous compounds obtainable from plant or animal sources contain the indole molecular structure. Indole plays a fundamental role for QS in E. coli, being one of the signal molecules responsible for the transcription of a variety of genes (gabT, and tnaB ASTD). COA of Formula: C8H3F2NO2
Referemce:
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