Safety of 1H-IndoleIn 2021 ,《New insights into gut-bacteria-derived indole and its derivatives in intestinal and liver diseases》 appeared in Frontiers in Pharmacology. The author of the article were Li, Xiaojing; Zhang, Binbin; Hu, Yiyang; Zhao, Yu. The article conveys some information:
A review. The interaction between host and microorganism widely affects the immune and metabolic status. Indole and its derivatives are metabolites produced by the metabolism of tryptophan catalyzed by intestinal microorganisms. By activating nuclear receptors, regulating intestinal hormones, and affecting the biol. effects of bacteria as signaling mols., indole and its derivatives maintain intestinal homeostasis and impact liver metabolism and the immune response, which shows good therapeutic prospects. We reviewed recent studies on indole and its derivatives, including related metabolism, the influence of diets and intestinal commensal bacteria, and the targets and mechanisms in pathol. conditions, especially progress in therapeutic strategies. New research insights into indoles will facilitate a better understanding of their dimmunity ruggability and application in intestinal and liver diseases. After reading the article, we found that the author used 1H-Indole(cas: 120-72-9Safety of 1H-Indole)
1H-Indole(cas: 120-72-9) belongs to indole. Indole, also called Benzopyrrole, a heterocyclic organic compound occurring in some flower oils, such as jasmine and orange blossom, in coal tar, and in fecal matter. It is used in perfumery and in making tryptophan, an essential amino acid, and indoleacetic acid (heteroauxin), a hormone that promotes the development of roots in plant cuttings.Safety of 1H-Indole
Referemce:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles