On July 1, 2021, Li, Yao; Chen, Lei; Wang, Wenjing; Zhang, Guobiao; Shi, Zongjun; Huang, Haitao; Zhao, Jianfei; Yang, Long; Liu, Guoliang; Huang, Shilin; Tang, Pingming; Ye, Fei; Zhang, Chen; Yan, Pangke published a patent.Computed Properties of 65417-22-3 The title of the patent was Preparation of the zeste enhancer homologue 2 inhibitor and their medical applications. And the patent contained the following:
The invention is related to the preparation of the zeste enhancer homolog 2 inhibitors I and their medical applications. The invention compounds I, wherein R1 is H, C1-4alkyl, halo, etc.; R2 is C1-4alkyl; (L1CRLaRLb)m-(NRLc)n-W-(NRLc)p-(CCRLaRLb)q; W is CO, SO2, CS, etc.; RLa and RLb are each independently selected from H, C1-4alkyl, halo etc.; RLc is H, C1-4alkyl, halo substituted C1-4alkyl; m, n, p ,q are each independently selected from 0, 1, 2, 3 or 4; X is C, N NRx1, etc.; Rx1 is H, C1-4alkyl, C3-6cycloalkyl; Rx2 is H, halo, C1-4alkyl, etc.; B is Ph, pyridyl, etc.; RB is H, C1-4alkyl, C1-4alkoxy, etc.; RB1 and RB2 each independently selected from H, C1-4alkyl, etc.; RB3 is C1-4alkyl, C3-6cycloalkyl, etc.; t is 0, 1, 2 or 3; R4 and R5 each independently selected from H, C1-4alkyl, halo substituted C1-4alkyl, etc.; s is 0, 1, 2 or 3; A is a 4-12 membered carbocyclic or heterocyclic ring containing 0-3 heteroatoms selected from N and S; and their stereoisomer, pharmaceutically acceptable salt, solvate and eutectic crystal are claimed. Compound I was prepared by multi-step procedure (procedure given). The invention compounds were evaluated for their EZH2 inhibitory activity. The experimental process involved the reaction of Methyl 2-methyl-1H-indole-3-carboxylate(cas: 65417-22-3).Computed Properties of 65417-22-3
The Article related to preparation zeste enhancer homolog inhibitor medical application, Heterocyclic Compounds (One Hetero Atom): Pyridines and other aspects.Computed Properties of 65417-22-3
Referemce:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles