Li, Yunyun; Qi, Zisong; Wang, He; Yang, Xifa; Li, Xingwei published an article in 2016, the title of the article was Ruthenium(II)-Catalyzed C-H Activation of Imidamides and Divergent Couplings with Diazo Compounds: Substrate-Controlled Synthesis of Indoles and 3H-Indoles.Electric Literature of 65417-22-3 And the article contains the following content:
Indoles are an important structural motif that is commonly found in biol. active mols. In this work, conditions for divergent couplings between imidamides and acceptor-acceptor diazo compounds were developed that afforded NH indoles I (R = Et, Me, tbu, Bn, Ac; R1 = H, 5-Me, 5-Br, 4-F, 6-Cl, etc) and 3H-indoles II (R = Et, Me, tBu, Bn, ipr, allyl; R1 = H, 5-Cl, 5-tbu, 5-CN, 5,6-diCl, etc) under ruthenium catalysis. The coupling of α-diazoketoesters afforded NH indoles by cleavage of the C(N2)-C(acyl) bond whereas α-diazomalonates gave 3H-indoles by C-N bond cleavage. This reaction constitutes the first intermol. coupling of diazo substrates with arenes by ruthenium-catalyzed C-H activation. The experimental process involved the reaction of Methyl 2-methyl-1H-indole-3-carboxylate(cas: 65417-22-3).Electric Literature of 65417-22-3
The Article related to diazoketoester imidamide ruthenium activation annulation catalyst, nh indole preparation, diazomalonate imidamide ruthenium activation annulation catalyst, indole 3h preparation, c−h activation, diazo compounds, indoles, ruthenium, transition-metal catalysis and other aspects.Electric Literature of 65417-22-3
Referemce:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles