In situ preparation of a ferric polymeric aluminum chloride-silica gel nanocatalyst by mechanical grinding and its solid-phase catalytic behavior in organic synthesis was written by Liang, Yuwang;Wang, Gang;Li, Xiang;Zhang, Qiuping;Zhan, Haijuan;Bi, Shuxian;Wu, Zhiqiang;Liu, Wanyi. And the article was included in New Journal of Chemistry in 2022.Application In Synthesis of 4-Nitroindole This article mentions the following:
In recent years, clean and sustainable mechanochem. solvent-free reactions have emerged as a viable alternative to solution chem. In order to completely solve the problem of environmental pollution caused by solvents and surfactants in LASC and LASSC systems, a green method for the in situ preparation of environmentally friendly inorganic polymeric Lewis acids and silica gel as nanocatalysts (PLASC) under solvent-free mech. grinding conditions was designed and realized by mechanochem. means, which is simple to operate and the process generates no other waste. Subsequently, 3-alkylindole derivatives (35-75%), 尾-amino alc. derivatives (90%), benzimidazole derivatives (85-90%) and quinoxaline derivatives (93-99%) were synthesized by a one-pot cooking method under continuous grinding conditions. The mechanism of in situ self-assembly of PAFC and silica gel on the silica gel surface under mech. forces and the new catalytically active species-Si-O-Al(Fe) polynuclear metal complexes resulting from chem. reforming were discovered and confirmed by SEM, HR-TEM, FT-IR, XRD and XPS tests as well as by solution morphol. studies. The true active center -O-Fe-O-Si-O-/-O-Si-O-Al-O- chem. bonding unit was revealed and found to be a nanoscale fibrous structure that is highly stable and can be reused at least 10 times without deactivation. The PLASC catalyst has remarkable green chem. properties such as easy recycling and a very low E factor, making it a new type of cheap, efficient and green catalyst. In the experiment, the researchers used many compounds, for example, 4-Nitroindole (cas: 4769-97-5Application In Synthesis of 4-Nitroindole).
4-Nitroindole (cas: 4769-97-5) belongs to indole derivatives. Indole, first isolated in 1866, and it is commonly synthesized from phenylhydrazine and pyruvic acid, although several other procedures have been discovered. Due to this activity, the indole ring system has become an important component or intermediate in the synthesis of heterocycles.Application In Synthesis of 4-Nitroindole
Referemce:
Indole alkaloid derivatives as building blocks of natural products from聽Bacillus thuringiensis聽and聽Bacillus velezensis聽and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles