On April 12, 2018, Lin, Hua; Long, Jonathan Z.; Roche, Alexander M.; Svensson, Katrin J.; Dou, Florence Y.; Chang, Mi Ra; Strutzenberg, Timothy; Ruiz, Claudia; Cameron, Michael D.; Novick, Scott J.; Berdan, Charles A.; Louie, Sharon M.; Nomura, Daniel K.; Spiegelman, Bruce M.; Griffin, Patrick R.; Kamenecka, Theodore M. published an article.Related Products of 79815-20-6 The title of the article was Discovery of Hydrolysis-Resistant Isoindoline N-Acyl Amino Acid Analogues that Stimulate Mitochondrial Respiration. And the article contained the following:
N-Acyl amino acids directly bind mitochondria and function as endogenous uncouplers of UCP1-independent respiration. The authors found that administration of N-acyl amino acids to mice improves glucose homeostasis and increases energy expenditure, indicating that this pathway might be useful for treating obesity and associated disorders. The authors report the full account of the synthesis and mitochondrial uncoupling bioactivity of lipidated N-acyl amino acids and their unnatural analogs. Unsaturated fatty acid chains of medium length and neutral amino acid head groups are required for optimal uncoupling activity on mammalian cells. A class of unnatural N-acyl amino acid analogs, characterized by isoindoline-1-carboxylate head groups, were resistant to enzymic degradation by PM20D1 and maintained uncoupling bioactivity in cells and in mice. The experimental process involved the reaction of H-Idc-OH(cas: 79815-20-6).Related Products of 79815-20-6
The Article related to isoindoline acyl amino acid mitochondria respiration, Pharmacology: Structure-Activity and other aspects.Related Products of 79815-20-6
Referemce:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles