Lindsay-Scott, Peter J. published the artcileUtilizing Solubility Differences to Achieve Regiocontrol in the Synthesis of Substituted Quinoline-4-carboxylic Acids, Safety of 4,5-Dichloroisatin, the main research area is isonitrosoacetanilide Sandmeyer reaction; isatin preparation regioselective Pfitzinger reaction; quinoline carboxylic acid preparation regioselective.
A practical method for the regiocontrolled synthesis of substituted quinoline-4-carboxylic acids was described. Solubility differences between the product quinoline regioisomers enabled their facile separation, thus avoiding any challenging chromatog. purifications and allowing access to highly substituted quinoline compounds in three steps from com. available anilines.
Synlett published new progress about Anilines Role: RCT (Reactant), RACT (Reactant or Reagent). 1677-47-0 belongs to class indole-building-block, name is 4,5-Dichloroisatin, and the molecular formula is C8H3Cl2NO2, Safety of 4,5-Dichloroisatin.
Referemce:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles