Gold-catalyzed stereoselective dearomatization/metal-free aerobic oxidation: access to 3-substituted indolines/oxindoles was written by Liu, Kai;Xu, Guangyang;Sun, Jiangtao. And the article was included in Chemical Science in 2018.Application In Synthesis of tert-Butyl 7-methoxy-1H-indole-1-carboxylate The following contents are mentioned in the article:
An unprecedented dearomatization of indoles with diazoesters was developed via cationic gold(I) catalysis. The functionalization selectively occurred at the C3-position to deliver methylene indole derivatives in good yields with excellent Z-selectivity, demonstrating unusual reactivity and selectivity compared with other noble metal catalysis. Importantly, simply followed by silica gel adsorption, an unprecedented metal-free aerobic oxidation occurred for indoles bearing N-electron donating substituents, provided a novel and efficient approach towards 3-substituted indolin-2-ones with a newly formed quaternary stereocenter in excellent stereoselectivity. Notably, these processes afforded direct and selective access to a variety of valuable intermediates from abundant feedstock chems. This study involved multiple reactions and reactants, such as tert-Butyl 7-methoxy-1H-indole-1-carboxylate (cas: 1215205-77-8Application In Synthesis of tert-Butyl 7-methoxy-1H-indole-1-carboxylate).
tert-Butyl 7-methoxy-1H-indole-1-carboxylate (cas: 1215205-77-8) belongs to indole derivatives. In addition to tryptophan, indigo, and indoleacetic acid, numerous compounds obtainable from plant or animal sources contain the indole molecular structure.Indole was synthesized in moderate yield via an o-naphthoquinone catalyzed tandem cross-coupling of substituted aniline and benzylamine under aerobic oxidation conditions.Application In Synthesis of tert-Butyl 7-methoxy-1H-indole-1-carboxylate
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Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles