Liu, Rui’s team published research in Microbes and Infection in 2022 | CAS: 120-72-9

1H-Indole(cas: 120-72-9) belongs to indole. Indole, also called Benzopyrrole, a heterocyclic organic compound occurring in some flower oils, such as jasmine and orange blossom, in coal tar, and in fecal matter. It is used in perfumery and in making tryptophan, an essential amino acid, and indoleacetic acid (heteroauxin), a hormone that promotes the development of roots in plant cuttings.COA of Formula: C8H7N

In 2022,Liu, Rui; Gao, Daqing; Fang, Zhengzou; Zhao, Lijiang; Xu, Zeyan; Qin, Chuyu; Zhang, Ruolan; Xu, Jinfeng; Lu, Chengping published an article in Microbes and Infection. The title of the article was 《AroC, a chorismate synthase, is required for the formation of Edwardsiella tarda biofilms》.COA of Formula: C8H7N The author mentioned the following in the article:

Biofilms contribute to the resistance of Edwardsiella tarda to antibiotics and host immunity. AroC in the shikimate pathway produces chorismate to synthesize crucial intermediates such as indole. In this study, the differences between biofilms produced by aroC mutants (aroC), wild-type (WT) strains, and aroC complementary strains (CaroC) were detected both in vitro with 96-well plates, tubes, or coverslips and in vivo using a mouse model of s.c. implants. When examining potential mechanisms, we found that the diameters of the movement rings in soft agar plates and the flagellar sizes and numbers determined by silver staining were all lower for aroC than for WT and CaroC. Moreover, qRT-PCR showed that the transcription levels of flagellar synthesis genes, fliA and fliC, were reduced in aroC. AroC, FliC, or FliA may accompany the motility of aroC strains. In addition, compared with the WT and CaroC, the amounts of indole in aroC were significantly decreased. Notably, the formation of biofilms by these strains could be promoted by exogenous indole. Therefore, the aroC gene could affect the biofilm formation of E. tarda concerning its impact on flagella and indole.1H-Indole(cas: 120-72-9COA of Formula: C8H7N) was used in this study.

1H-Indole(cas: 120-72-9) belongs to indole. Indole, also called Benzopyrrole, a heterocyclic organic compound occurring in some flower oils, such as jasmine and orange blossom, in coal tar, and in fecal matter. It is used in perfumery and in making tryptophan, an essential amino acid, and indoleacetic acid (heteroauxin), a hormone that promotes the development of roots in plant cuttings.COA of Formula: C8H7N

Referemce:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles