Liu, Xiao Gao; Jain, Rakesh K.; Saha, Raj; Matta, Khushi L. published an article in Bioorganic & Medicinal Chemistry Letters. The title of the article was 《Synthesis of Gal-β-(1→4)-6-O-SO3Na-GlcNAc-β-(1→6)-Man-α-OR as a part of glycoprotein (gp) 120》.Safety of Ethyl 3,4,6-tri-O-acetyl-2-deoxy-2-phthalimido-β-D-thioglucopyranoside The author mentioned the following in the article:
The synthesis of Gal-β-(1→4)-6-O-SO2Na-GlcNAc-β-(1→6)-Man-α-OR (as a part of gp 120) containing an anomeric p-nitrophenyl group was accomplished via stereoselective glycosidation of Et 3,4,6-tri-O-chloroacetyl-2-deoxy-2-phthalimido-1-thio-β-D-glucopyranoside. Title oligosaccharide can act as acceptor of α-2,3-sialyltransferase to give NeuAcα-(2→3)-Gal-β-(1→4)-6-O-SO2Na-GlcNAc-β-(1→6)-Man-α-OR which occurs as a part of gp 120. In the part of experimental materials, we found many familiar compounds, such as Ethyl 3,4,6-tri-O-acetyl-2-deoxy-2-phthalimido-β-D-thioglucopyranoside(cas: 99409-32-2Safety of Ethyl 3,4,6-tri-O-acetyl-2-deoxy-2-phthalimido-β-D-thioglucopyranoside)
Ethyl 3,4,6-tri-O-acetyl-2-deoxy-2-phthalimido-β-D-thioglucopyranoside(cas: 99409-32-2) belongs to indole.The indole subunit is an almost ubiquitous component of biologically active natural products, and its study has been the focus of research for decades.Safety of Ethyl 3,4,6-tri-O-acetyl-2-deoxy-2-phthalimido-β-D-thioglucopyranosideThey are capable of binding to a variety of receptors with high affinity and thus have applications in a wide range of therapeutic areas.
Referemce:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles