On February 4, 2016, Liu, Xiao-Guang; Li, Zi-Hao; Xie, Jian-Wei; Liu, Ping; Zhang, Jie; Dai, Bin published an article.Product Details of 65417-22-3 The title of the article was Copper-catalyzed synthesis of 2,3-disubstituted indoles from ortho-haloanilines and β-keto esters/β-diketone. And the article contained the following:
Tetrazole-1-acetic acid was identified as an efficient ligand to promote copper-catalyzed domino reaction of ortho-iodo/bromo-anilines RNH2 (R = 2-IC6H4, 2-I-5-H3CC6H3, 3-iodopyridin-2-yl, 2,4-Br2C6H3, etc.) with β-keto esters/β-diketone R1C(O)CH2C(O)R2 (R1 = CH3, (CH3)CH, C6H5, etc.; R2 = CH3, CH2CH3, OCH3, OCH2CH3) for 2,3-disubstituted indoles’ synthesis, e.g., I, with high yields under mild conditions. The protocol, with an easily-available catalytic system, shows good substrate tolerance towards various functional groups. The experimental process involved the reaction of Methyl 2-methyl-1H-indole-3-carboxylate(cas: 65417-22-3).Product Details of 65417-22-3
The Article related to indole preparation, ortho haloaniline dicarbonyl compound domino reaction copper catalyst, Heterocyclic Compounds (One Hetero Atom): Indoles, Indolizines, Carbazoles, and Other Arenopyrroles and other aspects.Product Details of 65417-22-3
Referemce:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles