Longeon, Arlette et al. published their research in Marine Drugs in 2011 | CAS: 18372-22-0

Methyl 2-(1H-indol-3-yl)-2-oxoacetate (cas: 18372-22-0) belongs to indole derivatives. Indole could be stereoselectively alkylated with chiral cyclopentyl sulfone reagent. More than 200 indole derivatives have already been marketed as drugs or are under advanced stages of clinical trials.Safety of Methyl 2-(1H-indol-3-yl)-2-oxoacetate

Bioactive indole derivatives from the South Pacific marine sponges Rhopaloeides odorabile and Hyrtios sp was written by Longeon, Arlette;Copp, Brent R.;Quevrain, Elodie;Roue, Melanie;Kientz, Betty;Cresteil, Thierry;Petek, Sylvain;Debitus, Cecile;Bourguet-Kondracki, Marie-Lise. And the article was included in Marine Drugs in 2011.Safety of Methyl 2-(1H-indol-3-yl)-2-oxoacetate This article mentions the following:

Indole derivatives including bromoindoles were isolated from the South Pacific marine sponges Rhopaloeides odorabile and Hyrtios sp. Their structures were established through anal. of mass spectra and 1- and 2-dimensional NMR spectroscopic data. Their potential inhibitory phospholipase A2 (PLA2), antioxidant and cytotoxic activities were evaluated. The new derivative 5,6-dibromo-L-hypaphorine (I) isolated from Hyrtios sp. revealed a weak bee venom PLA2 inhibition (IC50 0.2 mM) and a significant antioxidant activity with an Oxygen Radical Absorbance Capacity (ORAC) value of 0.22. The sesquiterpene aureol, also isolated from Hyrtios sp., showed the most potent antioxidant activity with an ORAC value of 0.29. In the experiment, the researchers used many compounds, for example, Methyl 2-(1H-indol-3-yl)-2-oxoacetate (cas: 18372-22-0Safety of Methyl 2-(1H-indol-3-yl)-2-oxoacetate).

Methyl 2-(1H-indol-3-yl)-2-oxoacetate (cas: 18372-22-0) belongs to indole derivatives. Indole could be stereoselectively alkylated with chiral cyclopentyl sulfone reagent. More than 200 indole derivatives have already been marketed as drugs or are under advanced stages of clinical trials.Safety of Methyl 2-(1H-indol-3-yl)-2-oxoacetate

Referemce:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles