伪-Xanthylmethyl Ketones from 伪-Diazo ketones was written by Lopez-Mendoza, Pedro;Miranda, Luis D.. And the article was included in Synthesis in 2021.SDS of cas: 6639-06-1 This article mentions the following:
A simple and efficient method to obtain 伪-xanthylmethyl ketones from 伪-diazo ketones is described. The reaction proceeds through a protonation/nucleophilic substitution sequence in the presence of p-toluenesulfonic acid and potassium Et xanthogenate as the nucleophile. As 伪-diazo ketones can be readily synthesized from ubiquitous carboxylic acids, a broad variety of xanthates can be obtained, including examples from naturally occurring substrates. In the experiment, the researchers used many compounds, for example, 3-(1H-Indol-1-yl)propanoic acid (cas: 6639-06-1SDS of cas: 6639-06-1).
3-(1H-Indol-1-yl)propanoic acid (cas: 6639-06-1) belongs to indole derivatives. Indole is an important structural motif of various drugs, therapeutic leads besides its prevalence in numerous natural products, agrochemicals, perfumery, and dyes. In addition to indole, the strain-release chemistry worked for numerous substrates including amines, alcohols, thiols, carboxylic acids, imidazoles, and pyrazoles.SDS of cas: 6639-06-1
Referemce:
Indole alkaloid derivatives as building blocks of natural products from聽Bacillus thuringiensis聽and聽Bacillus velezensis聽and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles