Lopez-Valdez, German published the artcileConvenient access to isoindolinones via carbamoyl radical cyclization: Synthesis of cichorine and 4-hydroxyisoindolin-1-one natural products, Recommanded Product: 4-Hydroxy-2,3-dihydroisoindol-1-one, the main research area is isoindolinone preparation oxidative radical cyclization; cichorine synthesis oxidative radical cyclization; hydroxyisoindolinone synthesis oxidative radical cyclization; zinnimidine formal synthesis oxidative radical cyclization.
An efficient and convenient access to 2-tert-butylisoindolin-1-ones via an oxidative radical cyclization process from stable carbamoylxanthates, derived from secondary tert-butylamines, is described. The proposed mechanism for this transformation involves, the generation of a carbamoyl radical, its cyclization to the aromatic system, and the dilauroyl peroxide (DLP) mediated rearomatization to generate the isoindolinone ring system. Addnl., the syntheses of cichorine and 4-hydroxyisoindolin-1-one natural products were carried out to underscore the synthetic potential of this xanthate-based carbamoyl radical-oxidative cyclization.
Tetrahedron published new progress about Radical oxidative cyclization. 366453-21-6 belongs to class indole-building-block, name is 4-Hydroxy-2,3-dihydroisoindol-1-one, and the molecular formula is C8H7NO2, Recommanded Product: 4-Hydroxy-2,3-dihydroisoindol-1-one.
Referemce:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles