Iodine-catalyzed C3-formylation of indoles via C-N bond cleavage of tertiary amines under aerobic conditions was written by Lu, Lin;Xiong, Qiheng;Guo, Shengmei;He, Tianqiang;Xu, Feng;Gong, Jiuhan;Zhu, Zheng;Cai, Hu. And the article was included in Tetrahedron in 2015.Category: indole-building-block This article mentions the following:
A novel route was developed for the C3-formation of indoles using iodine as the catalyst. This transformation involves the cleavage of the C-N bond of tertiary amines by the Cross-Dehydrogenative Coupling reaction (CDC), and is well tolerated by a range of 1H-indoles under aerobic conditions. Moreover, this method can be applied to gram-scale synthesis. In the experiment, the researchers used many compounds, for example, 5-Chloroindole-3-carboxaldehyde (cas: 827-01-0Category: indole-building-block).
5-Chloroindole-3-carboxaldehyde (cas: 827-01-0) belongs to indole derivatives. Indole, also called Benzopyrrole, a heterocyclic organic compound occurring in some flower oils, such as jasmine and orange blossom, in coal tar, and in fecal matter. More than 200 indole derivatives have already been marketed as drugs or are under advanced stages of clinical trials.Category: indole-building-block
Referemce:
Indole alkaloid derivatives as building blocks of natural products from聽Bacillus thuringiensis聽and聽Bacillus velezensis聽and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles