In 2019,Nature (London, United Kingdom) included an article by Lv, Jiahang; Chen, Xiangyang; Xue, Xiao-Song; Zhao, Binlin; Liang, Yong; Wang, Minyan; Jin, Liqun; Yuan, Yu; Han, Ying; Zhao, Yue; Lu, Yi; Zhao, Jing; Sun, Wei-Yin; Houk, Kendall. N.; Shi, Zhuangzhi. Related Products of 120-72-9. The article was titled 《Metal-free directed sp2-C-H borylation》. The information in the text is summarized as follows:
Direct borylation of 1- or 3-pivaloyl-1H-indoles was achieved by reaction with BBr3 with subsequent esterification with pinacol, yielding 7- or 4-indoleboronates, resp., without use of metal catalyst. N-acylated aromatic amines were successfully borylated into o-position with the same protocol, giving 2-pivaloylaminophenylboronic acids. Organoboron reagents are important synthetic intermediates that have a key role in the construction of natural products, pharmaceuticals and organic materials. The discovery of simpler, milder and more efficient approaches to organoborons can open addnl. routes to diverse substances. Here we show a general method for the directed C-H borylation of arenes and heteroarenes without the use of metal catalysts. C7- and C4-borylated indoles are produced by a mild approach that is compatible with a broad range of functional groups. The mechanism, which is established by d. functional theory calculations, involves BBr3 acting as both a reagent and a catalyst. The potential utility of this strategy is highlighted by the downstream transformation of the formed boron species into natural products and drug scaffolds. In addition to this study using 1H-Indole, there are many other studies that have used 1H-Indole(cas: 120-72-9Related Products of 120-72-9) was used in this study.
1H-Indole(cas: 120-72-9) belongs to indole. Indole, also called Benzopyrrole, a heterocyclic organic compound occurring in some flower oils, such as jasmine and orange blossom, in coal tar, and in fecal matter. It is used in perfumery and in making tryptophan, an essential amino acid, and indoleacetic acid (heteroauxin), a hormone that promotes the development of roots in plant cuttings.Related Products of 120-72-9
Referemce:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles