Access to Polycyclic Thienoindolines via Formal [2+2+1] Cyclization of Alkynyl Indoles with S8 and K2S was written by Ma, Jinhui;Luo, Jiajun;Jiang, Kai;Zhang, Guangwen;Liu, Shubin;Yin, Biaolin. And the article was included in Organic Letters in 2021.Application In Synthesis of 5-Chloroindole-3-carboxaldehyde This article mentions the following:
Herein, a protocol for accessing polycyclic dihydrothiophenes I (R1 = H, 10-F, 9-Cl, 8-Br, etc.; R2 = Ph, 4-FC6H4, 3,4-Me2C6H4, etc.; R3 = Et, i-Pr, n-Pr, PhCH2; R4 = H, Me) by means of formal [2+2+1] intramol. dearomatizing cyclization of alkynyl indoles II with K2S and S8 as the sources of sulfide is reported. In addition, tetrahydrothienoindolines III (R1-R3 as above) were stereoselectively synthesized from the corresponding II (R4 = H) via a one-pot, two-step protocol involving AgNO3-catalyzed alkenyl dearomatization followed by two nucleophilic addition reactions involving K2S. In the experiment, the researchers used many compounds, for example, 5-Chloroindole-3-carboxaldehyde (cas: 827-01-0Application In Synthesis of 5-Chloroindole-3-carboxaldehyde).
5-Chloroindole-3-carboxaldehyde (cas: 827-01-0) belongs to indole derivatives. Indole exists overwhelmingly in the 1H-indole form as do other simple indoles.Indole was synthesized in moderate yield via an o-naphthoquinone catalyzed tandem cross-coupling of substituted aniline and benzylamine under aerobic oxidation conditions.Application In Synthesis of 5-Chloroindole-3-carboxaldehyde
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Indole alkaloid derivatives as building blocks of natural products from聽Bacillus thuringiensis聽and聽Bacillus velezensis聽and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles