Ma, Rui-Jun published the artcileSynthesis of 1-benzylisoindoline and 1-benzyl-tetrahydroisoquinoline through nucleophilic addition of organozinc reagents to N,O-acetals, Category: indole-building-block, the main research area is benzylisoindoline preparation; benzyl tetrahydroisoquinoline preparation; organozinc compound acetal nucleophilic addition.
A new approach to access 1-benzylisoindolines I [n = 1, 2; R1 = Bn, 4-FC6H4CH2, 4-t-BuC6H4CH2, etc.; R2 = H, 5-Br, 6-Cl, etc.] and 1-benzyl-tetrahydroisoquinolines I [R2 = H, 6,7-di-OMe] was developed through nucleophilic addition of organozinc reagents to N,O-acetals. A number of substituted organozinc reagents were amenable for this transformation, and the desired products were obtained with excellent yields. Moreover, Sc(OTf)3 proved to be an effective catalyst for the formation of 1-benzylisoindolines I and 1-benzyl-tetrahydroisoquinolines II using such nucleophilic addition
Organic & Biomolecular Chemistry published new progress about Isoindoles Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 74572-29-5 belongs to class indole-building-block, name is 5-Chloroisoindolin-1-one, and the molecular formula is C8H6ClNO, Category: indole-building-block.
Referemce:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles