SDS of cas: 100-51-6. Che, JW; Niu, L; Jia, SK; Xing, D; Hu, WH in [Che, Jiuwei; Niu, Li; Xing, Dong] East China Normal Univ, Sch Chem & Mol Engn, Shanghai Engn Res Ctr Mol Therapeut & New Drug De, Shanghai 200062, Peoples R China; [Jia, Shikun; Hu, Wenhao] Sun Yat Sen Univ, Sch Pharmaceut Sci, Guangdong Key Lab Chiral Mol & Drug Discovery, Guangzhou 510006, Peoples R China published Enantioselective three-component aminomethylation of alpha-diazo ketones with alcohols and 1,3,5-triazines in 2020.0, Cited 66.0. The Name is Benzyl Alcohol. Through research, I have a further understanding and discovery of 100-51-6.
Enantioselective alpha-aminomethylation of carbonyl compounds constitutes a powerful protocol for introducing aminomethyl groups to simple organic molecules. However, current strategies rely on nucleophile-based enantioselective activation with inherently activated substrates only, and enantioselective protocol based on the activation of in situ-generated unstable formaldimines remains elusive, probably owing to their unstable nature and the lack of steric environment for efficient stereocontrols. Here, based on a rhodium/chiral phosphoric acid cooperative catalysis, we achieved an enantioselective three-component reaction of alpha-diazo ketones with alcohols and 1,3,5-triazines. A dual hydrogen bonding between the chiral phosphoric acid catalyst and two distinct active intermediates was proposed to be crucial for the efficient electrophile-based enantiocontrol. A series of chiral beta-amino-alpha-hydroxy ketones including those derived from simple aliphatic alcohols, allylic alcohol, propargyl alcohol, complicated natural alcohols and water could all be prepared in high efficiency and enantioselectivity.
SDS of cas: 100-51-6. About Benzyl Alcohol, If you have any questions, you can contact Che, JW; Niu, L; Jia, SK; Xing, D; Hu, WH or concate me.
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