Maddela, Srinubabu published the artcileSynthesis of isatin-quinoline conjugates as possible biologically active agents, Recommanded Product: 4,5-Dichloroisatin, the main research area is isatin quinoline conjugate preparation antibacterial antifungal antiinflammatory; quinolinyl hydrazide isatin condensation.
A series of 12 new quinoline-3-carbohydrazide derivatives I (R = H, 5-F, 4-Cl, 7-Cl, etc.) were synthesized by the condensation of quinolinyl hydrazide with different isatins. The synthesized compounds were evaluated for in vitro antimicrobial and in vivo anti-inflammatory activity. Tested compounds exhibited moderate to good antibacterial and antifungal activity. Evaluation of the compounds revealed remarkable anti-inflammatory activity and were comparable with standard, indomethacin. Compounds I (R = 5-O2N, 5-F, 7-Cl, 4-Cl) inhibited paw edema in a carrageenan-induced rat hind paw edema model.
Toxicological & Environmental Chemistry published new progress about Anti-inflammatory agents. 1677-47-0 belongs to class indole-building-block, name is 4,5-Dichloroisatin, and the molecular formula is C8H3Cl2NO2, Recommanded Product: 4,5-Dichloroisatin.
Referemce:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles