Fate of pharmaceuticals and their transformation products in integrated membrane systems for wastewater reclamation was written by Mamo, J.;Garcia-Galan, M. J.;Stefani, M.;Rodriguez-Mozaz, S.;Barcelo, D.;Monclus, H.;Rodriguez-Roda, I.;Comas, J.. And the article was included in Chemical Engineering Journal (Amsterdam, Netherlands) in 2018.Reference of 15362-40-0 This article mentions the following:
The removal of pharmaceuticals (PhACs) from urban wastewater by membrane bioreactors (MBRs) followed by reverse osmosis (RO) or nanofiltration (NF) membranes has been frequently addressed in the literature. However, data regarding the removal of their main human metabolites and transformation products (TPs) is still scarce. Here, the presence of 13 PhACs and 20 of their metabolites and TPs was monitored during 2 consecutive years in the different treatment steps of urban raw wastewater (sewer, primary treatment, MBR and RO/NF). Rejection of the selected contaminants when using low pressure NF membranes (NF-90) or RO membranes (ESPA 2) after the MBR step was also studied. The analgesic acetaminophen, which was found at the highest concentrations in the sewer and influent samples (18-74 渭g/L) over the 2 exptl. periods, was fully eliminated during MBR treatment. Those PhACs that were only partially removed after the MBR, were almost completely removed (>99%) by the RO membrane working under different process conditions. At a similar average permeate fluxes (18 L/m2-h), the NF membrane showed high removal efficiencies (>90%) for all of the PhACs and their metabolites, though lower than those achieved by the RO membrane. When the flux of the NF90 membrane was increased to 30 L/m2-h (while still operating at a feed pressure lower than the RO membrane at 18 L/m2-h) the performance of the membrane increased, achieving 98% rejection of PhACs. In the experiment, the researchers used many compounds, for example, 1-(2,6-Dichlorophenyl)-2-indolinone (cas: 15362-40-0Reference of 15362-40-0).
1-(2,6-Dichlorophenyl)-2-indolinone (cas: 15362-40-0) belongs to indole derivatives. Indole, first isolated in 1866, and it is commonly synthesized from phenylhydrazine and pyruvic acid, although several other procedures have been discovered. Indole plays a fundamental role for QS in E. coli, being one of the signal molecules responsible for the transcription of a variety of genes (gabT, and tnaB ASTD). Reference of 15362-40-0
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Indole alkaloid derivatives as building blocks of natural products from聽Bacillus thuringiensis聽and聽Bacillus velezensis聽and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles