Marcin, Lawrence R.; Denhart, Derek J.; Mattson, Ronald J. published the artcile< Catalytic Asymmetric Diazoacetate Cyclopropanation of 1-Tosyl-3-vinylindoles. A Route to Conformationally Restricted Homotryptamines>, Application In Synthesis of 4771-48-6, the main research area is homotryptamine preparation vinylindole diazoacetate asym cyclopropanation.
Substituted 1-tosyl-3-vinylindoles undergo catalytic asym. cyclopropanation with Et and tert-Bu diazoacetate to afford N-protected trans-2-(indol-3-yl)-1-cyclopropanecarboxylic esters in good yield and high enantiomeric excess (81-88% ee). The resulting cycloadducts are demonstrated to be useful intermediates for the synthesis of conformationally restricted, homotryptamine-like analogs such as BMS-505130 (I.maleate).
Organic Letters published new progress about Cyclopropanation catalysts, stereoselective. 4771-48-6 belongs to class indole-building-block, and the molecular formula is C10H9NO, Application In Synthesis of 4771-48-6.
Referemce:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles