Novel bis(tetrahydropyrrolo[3,4-b]carbazoles) linked with aliphatic chains: synthesis and structural aspects was written by Meyer, Kerstin U.;Pindur, Ulf. And the article was included in Journal of the Chemical Society, Perkin Transactions 1 in 2001.Recommanded Product: 4583-55-5 This article mentions the following:
Dehydrohalogenation of 2,3-bis(bromomethyl)-1H-indole-1-carboxylic acid Me ester gave 2,3-dihydro-2,3-bis(methylene)-1H-indole-1-carboxylic acid Me ester derivatives Diels-Alder reaction of these 2,3-dihydro-2,3-bis(methylene)-1H-indole-1-carboxylic acid Me ester derivatives with N,N‘-trimethylenedimaleimide, N,N‘-tetramethylenedimaleimide, or N,N‘-dodecamethylenedimaleimide gave 2,2’-(alkanediyl)bis[dioxopyrrolo[3,4-b]carbazolecarboxylate] derivatives (i.e., the title compounds containing aliphatic chain linkages). These conformationally highly flexible mols. represent an interesting class of compounds, believed to have an affinity towards DNA, as potential DNA ligands. Pharmacol. test data were not reported. In the experiment, the researchers used many compounds, for example, 5-Bromo-2,3-dimethyl-1H-indole (cas: 4583-55-5Recommanded Product: 4583-55-5).
5-Bromo-2,3-dimethyl-1H-indole (cas: 4583-55-5) belongs to indole derivatives. In addition to tryptophan, indigo, and indoleacetic acid, numerous compounds obtainable from plant or animal sources contain the indole molecular structure. More than 200 indole derivatives have already been marketed as drugs or are under advanced stages of clinical trials.Recommanded Product: 4583-55-5
Referemce:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles