Miller, David D.’s team published research in Bioorganic & Medicinal Chemistry Letters in 21 | CAS: 860624-90-4

Bioorganic & Medicinal Chemistry Letters published new progress about 860624-90-4. 860624-90-4 belongs to indole-building-block, auxiliary class Indole,Bromide,Carboxylic acid,Indole, name is 5-Bromo-1H-indole-7-carboxylic acid, and the molecular formula is C9H6BrNO2, COA of Formula: C9H6BrNO2.

Miller, David D. published the artcile3,5-Disubstituted-indole-7-carboxamides: The discovery of a novel series of potent, selective inhibitors of IKK-β, COA of Formula: C9H6BrNO2, the publication is Bioorganic & Medicinal Chemistry Letters (2011), 21(8), 2255-2258, database is CAplus and MEDLINE.

The discovery and hit-to-lead exploration of a novel series of selective IKK-β kinase inhibitors is described. The initial lead fragment 3 (I) was identified by pharmacophore-directed virtual screening. Homol. model-driven SAR exploration of the template led to potent inhibitors, such as 12 (II), which demonstrate efficacy in cellular assays and possess encouraging developability profiles.

Bioorganic & Medicinal Chemistry Letters published new progress about 860624-90-4. 860624-90-4 belongs to indole-building-block, auxiliary class Indole,Bromide,Carboxylic acid,Indole, name is 5-Bromo-1H-indole-7-carboxylic acid, and the molecular formula is C9H6BrNO2, COA of Formula: C9H6BrNO2.

Referemce:
https://www.nature.com/articles/s41429-020-0333-2,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles