Cinnamoyl amide type chiral P,olefin ligands for Pd-catalyzed reactions was written by Mino, Takashi;Fujisawa, Yohei;Yoshida, Shizuki;Hirama, Mitsuru;Akiyama, Takumu;Saito, Ryo;Yoshida, Yasushi;Kasashima, Yoshio;Sakamoto, Masami. And the article was included in Organic & Biomolecular Chemistry in 2021.Electric Literature of C8H6N2O2 This article mentions the following:
Cinnamoyl amide type chiral P,olefin ligands are synthesized. Authors successfully obtained separable diastereomers of I with axial chirality and demonstrated Pd-catalyzed asym. allylic substitution reactions of indoles using compound I as a chiral ligand with high enantioselectivities (up to 98% ee). In the experiment, the researchers used many compounds, for example, 6-Nitro-1H-indole (cas: 4769-96-4Electric Literature of C8H6N2O2).
6-Nitro-1H-indole (cas: 4769-96-4) belongs to indole derivatives. Indole is an important structural motif of various drugs, therapeutic leads besides its prevalence in numerous natural products, agrochemicals, perfumery, and dyes. In addition to indole, the strain-release chemistry worked for numerous substrates including amines, alcohols, thiols, carboxylic acids, imidazoles, and pyrazoles.Electric Literature of C8H6N2O2
Referemce:
Indole alkaloid derivatives as building blocks of natural products from聽Bacillus thuringiensis聽and聽Bacillus velezensis聽and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles