Mizrahi, Dana M. et al. published their research in Phosphorus, Sulfur and Silicon and the Related Elements in 2001 | CAS: 3130-75-4

伪-Amino acid derived bisphosphonates. Synthesis and anti-resorptive activity was written by Mizrahi, Dana M.;Waner, Trevor;Segall, Yoffi. And the article was included in Phosphorus, Sulfur and Silicon and the Related Elements in 2001.Quality Control of 4-(1,3-Dioxoisoindolin-2-yl)butanoic acid This article mentions the following:

Eleven new bisphosphonates were prepared from naturally-occurring L-amino acids. The synthesis required special attention to amino and side-chain protections. The novel compounds were tested in TPTX (thyroparathyroidectomized) rats against arotinoid-induced hypercalcemia and were compared to alendronate. Leucine and phenylalanine bisphosphonates showed modest antiresorptive activity, as compared to alendronate. Limited SAR conclusions were drawn. In the experiment, the researchers used many compounds, for example, 4-(1,3-Dioxoisoindolin-2-yl)butanoic acid (cas: 3130-75-4Quality Control of 4-(1,3-Dioxoisoindolin-2-yl)butanoic acid).

4-(1,3-Dioxoisoindolin-2-yl)butanoic acid (cas: 3130-75-4) belongs to indole derivatives. Indole could be stereoselectively alkylated with chiral cyclopentyl sulfone reagent. More than 200 indole derivatives have already been marketed as drugs or are under advanced stages of clinical trials.Quality Control of 4-(1,3-Dioxoisoindolin-2-yl)butanoic acid

Referemce:
Indole alkaloid derivatives as building blocks of natural products from聽Bacillus thuringiensis聽and聽Bacillus velezensis聽and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles